BUY WKYMVM

WKYMVM. A Potent Agonist of FPR2 and FPR3 G-Protein Coupled Receptors.

Chemotactic factors from both Gram-positive and Gram-negative bacteria are short peptides with N-formyl methionine at the N-terminus (extensively reviewed in reference 1). These peptides are released from bacteria during infection and activate formyl peptide receptor (FPR), a member of G-protein coupled receptors (GPCRs). In human, the FPR family consists mainly of three receptors, FPR1, FPR2/ALX (formerly FPRL1), and FPR3 (formerly FPRL2) which all couple to theG\_i\subtype of G-proteins and ultimately lead to the activation of phospholipase C and intracellular Ca²⁺increase.
WKYMVM is a selective agonist of the Formyl peptide receptors (FPR2 and FPR3) and was discovered by screening peptide libraries for their ability to stimulate inositol phosphates in lymphocyte cell lines. FPR2 is expressed in the promyelocytic leukemia cell line HL-60 as well as in the chronic myelogenous leukemia cell line K562.
WKYMVM triggered the activity of NADPH oxidase and generation of superoxide anions in human neutrophils. In mouse dendritic cells, WKYMVM triggered Ca²⁺signals in a pertussis toxin dependent manner, leading to increased phagocytosis via phospholipase D activation. G-Protein Coupled Receptor Ligands; Formylpeptide Receptor Ligands.