logo
logo
BUY Azelnidipine

Cat no: A-135

BUY Azelnidipine

Both L-type (CaV1) and T-type (CaV3) voltage gated Ca2+ channels are large (~0.5 MDa), transmembrane proteins which control the cellular influx of Ca2+ in response to electrical stimulus; while CaV1s require a strong depolarization (~+40 mV) to perform, a much weaker pulse (~-40 mV) is sufficient to activate CaV3s.\n\nCa2+ channel blockers (CCBs) are a diverse class of pharmaceutical agents, usually targeting L-type channels, of which dihydropyridines (DHPs) constitute a major subgroup. Inhibitors of Ca2+-mediated smooth muscle contractions, CCBs produce vasodilation, thus therapeutically managing hypertension and coronary heart disease.\n\nAn antagonist of both CaV1 (all subtypes) and CaV3 ((A)1G and (A)1H subtypes), azelnidipine (AZL) is a DHP derivate known to target CaVs with an IC50 of 3 nM. Its long-lasting interaction at multiple binding sites of L-type Ca2+ channels renders it resistant to S(-)-Bay K 8644 (CaV1 channel agonist) activating effects, otherwise shown to counteract nifedipine-induced inhibition; AZL thus confers significantly prolonged cardioactive time. Its reduced side effects and improved cardiovagal baroreflex sensitivity (BRS) when clinically administered make ALZ's therapeutic benefits superior to that of the potent antihypertensive, amlodipine. Additionally, ALZ possesses hydragogue, heart-protective, kidney-protective, and anti-arteriosclerosis capabilities.

Prices direct from Alomone Labs Limited.

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

A-135

Size

50 mg

Purity

>98%

Concentration

1-100 uM

Shipping Temp

Room Temperature

Molecular Weight

582.65 Da

Latest promotions

New brilliant antibodies, and new lower prices!For flow cytometry reagents in general, \"bright is better.\" The violet-excitable BD Horizon™ BV421 and...

Buy any polyclonal or monoclonal antibody from our extensive range of pre-made antibodies and for a limited time only receive a $50 discount!(T&C apply:...

We're so sure that you'll prefer Cayman Assay kits over your present brand that we're willing to give you a free assay kit to prove it!

For the past decade scientists have extensively used ATS secondary toxin conjugates to make their own targeted toxins for in vitro use.The ability to combine...

10% Discount on 2 Rabbit Polyclonal Antibody Service. With over 20 years experience, SDIX has developed into the premier US custom antibody producer,...

Did your supplier increase the price of Fetal Bovine Serum? Did they substitute the US Origin with USDA? Well say no more! Innovative Research is still...

Bulk Cytokines with Custom Vialing.20 - 50% off cytokines, growth factors, chemokines and more...For a limited time Cell Sciences is offering substantial...

Are you planning to have a customised antibody made for your research?Since 2000, Everest has been producing a catalog containing thousands of affinity...