

Supplier:
Alomone Labs Limited.Cat no: A-140
BUY Amiloride hydrochloride
Amiloride is a well-known antagonist of ENaC, Na+/Ca2+, and Na+/H+ exchangers, nonselective cation channels, and voltage-gated K+ and Ca2+ channels. It has been extensively used as a probe for a wide variety of transport systems.
Acid-sensing ion channels (ASICs) are expressed in various sensory and central neurons. Six different ASIC subunits have been cloned, which are encoded by four genes (ASIC1пїЅASIC4). Amiloride is a nonselective ASIC blocker and the channels cloned all belong to the Amiloride-sensitive Na+-channel. The IC50 values for Amiloride block of ASIC in PC12 cells are 0.2-0.7 μM, values which are ~10пїЅ20 times lower than its block of ASICs in central and sensory neurons.
TRPP3, a member of the transient receptor potential (TRP) superfamily of cation channels, is a Ca2+-activated nonselective cation channel permeable to Ca2+, K+, Na+, Rb+, NH4, and Ba2+, inhibited by Mg2+, H+, La3+, and Gd3+. TRPP3 is localized to a subset of taste receptor cells in the tongue, where it may play a crucial role in sour tasting, and to neurons surrounding the central canal of the spinal cord, where it may account for the long-sought proton-dependent regulation of the frequency of action potential.
Amiloride inhibits TRPP3 channel activity in Xenopus oocytes with an IC50 value of 143 μM.
Ion Channel Modulators; ASIC Channel Blockers.
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SPECIFICATIONS
Catalog Number
A-140
Size
1 g
Purity
>99%
Concentration
0.2 uM - 5 mM
Shipping Temp
Room Temperature
Molecular Weight
266.09 Da
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