Verruculogen. A Mycotoxin Blocker of KCa1.1 (BK) Channels.
Verruculogen is�a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK)�channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include�Pentrium A�(#P-650) and�Paxilline�(#P-450).
Verruculogen enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine. Verruculogen had similar effects to�Iberiotoxin�(#STI-400) in inhibiting the early Ca2+�dependent K+�current in CA1 pyramidal cells.
Ion Channel Modulators; K+ Channel Blockers
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