Supplier:
Alomone Labs Limited.Cat no: V-100
BUY Verapamil HCI
L-type (Cav1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases.
Verapamil HCl is a phenylalkylamine that acts as a L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension. Verapamil is also effective in treating arrytmias. Verapamil block of L-type channels is dependent on the membrane potential. The IC50 values at a holding potential of -80 or -40 mV are 250 and 15.5 μM, respectively. In Xenopus oocytes, Verapamil inhibits L-type currents in an activity dependent manner. Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
V-100
Size
10 g
Purity
>99%
Concentration
1-250 uM
Shipping Temp
Room Temperature
Molecular Weight
491.1 da
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