BUY Verapamil HCI

Verapamil HCl. A Phenylalkylamine�L-type�Ca²⁺ Channel Blocker.
L-type (Ca_v1), voltage-gated Ca²⁺ channels are plasma membrane protein complexes which allow the passage of Ca²⁺ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases.

Verapamil HCl is a phenylalkylamine that acts as a L-type, voltage-gated Ca²⁺ channel blocker and is used in the clinic to treat hypertension. Verapamil is also effective in treating arrytmias. Verapamil block of L-type channels is dependent on the membrane potential. The IC₅₀ values at a holding potential of -80 or -40 mV are 250 and 15.5 μM, respectively. In Xenopus oocytes, Verapamil inhibits L-type currents in an activity dependent manner. Ion Channel Modulators; Voltage - Gated Ca²⁺ Channel Blockers.