Supplier:
Alomone Labs Limited.Cat no: T-700
BUY Tyrphostin AG 490
Tyrphostin AG-490 (AG-490) is synthetic tyrphostin derivated from benzylidine malononitrile. At relatively low concentrations, AG-490 was found to be a highly efficient tyrosine kinase inhibitor for hyperactive forms of Jun kinase 2, 3 and 5 (Jak 2,3, and 5).
While many kinase inhibitors are often promiscuous in the enzymes they target, AG-490 is unique in that it does not inhibit other lymphocytic tyrosine kinases such as Lck, Lyn, Btk, Syk, Src, Jak1, Zap70 or Tyk2. AG-490 has also been shown to inhibit cytokine-induced activation of JAK2 in eosinophils stimulated with granulocyte-macrophage and in vascular smooth muscle cells and cardiac myocytes activated by angiotensin
Some studies have demonstrated that AG-490 efficiently blocks STAT3 activation in mycosis fungoides-derived T cell lymphoma cells and induces apoptosis in myeloma cells.
Protein Kinase Inhibitors and Activators; JAK Inhibitor.
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SPECIFICATIONS
Catalog Number
T-700
Size
10 x 1 mg
Purity
>99%
Concentration
10 nM - 1 micro M
Shipping Temp
Room Temperature
Molecular Weight
294.31
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