Tityustoxin K alpha. A Potent and Specific Blocker of Kv1.2 Channels
Tityustoxin-K α, was originally isolated from the scorpion Tityus serrulatus, and was shown to block cloned Kv1.2 with high potency. It inhibits stably expressed Kv1.2 channels in fibroblast cell line as assessed by patch clamp with Kd of 0.21 nM. Tityustoxin-K alpha also reduced the binding of 125I- alpha-Dendrotoxin to synaptosomal membranes.
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