Tertiapin.
A Peptide Blocker of Inward Rectifier (K\ir\) K\+\ Channels
Tertiapin is a 21 amino acid long toxin, originally isolated from Apis mellifera bee venom.
Native and synthetic Tertiapin block a range of inward rectifier K\+\ channels. (K\ir\), in particular ROMK1 (K\ir\1.1, IC50 = 2nM) and GIRK (K\ir\3 family, IC50 for the K\ir\3.1/3.4 heteromer is 8.6 nM) but with no effect on K\ir\2 family members.
In addition, it was shown to inhibit acetylcholine induced K\+\ currents in heart.
Alomone Labs is pleased to offer Tertiapin (#STT-250)�a synthetic peptide purified to homogeneity.
Tertiapin is as active as Tertiapin-Q (#STT-170), a derivative of Tertiapin in which the oxidation-liable methionine is replaced by a�glutamine residue.
Ion Channel Modulators; K+ Channel Blockers
Quick Search
Products 
