Supplier:
Alomone Labs Limited.Cat no: STT-170
BUY Tertiapin-Q
The native toxin Tertiapin was originally isolated fromпїЅEuropeanпїЅhoney beeпїЅApis melliferaпїЅvenom.пїЅпїЅNative and synthetic Tertiapin blocks a range of inward rectifier K+channels (Kir),пїЅin particular ROMK1 (Kir1.1, IC50=2 nM) and GIRK (Kir3 family, IC50пїЅfor theпїЅKir3.1/3.4 heteromer was 8.6 nM) but with no effect on Kir2 family member.пїЅIn accordance, it was shown to inhibit acetylcholine induced K+пїЅcurrents inпїЅmammalian cardiomyocytes.
Tertiapin-Q is a derivative of Tertiapin in which Met13пїЅisпїЅsubstitutedпїЅby Gln residue. However, unlike native Tertiapin, Tertiapin-Q is non-oxidizable and therefore is more stable.
Tertiapin-Q inhibits the above-mentioned channels with similar affinities and alsoпїЅinhibits Ca2пїЅactivated large conductance BK-type K+пїЅchannels in a concentration, and voltage-dependent manner.
Alomone Labs is pleased to offer Tertiapin-Q,пїЅa purified synthetic peptideпїЅin economical sizesпїЅand atпїЅvery attractive prices.
Ion Channel Modulators; K+ Channel Blockers
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SPECIFICATIONS
Catalog Number
STT-170
Size
5 micro g
Purity
>98%
Concentration
2-200 nM.
Shipping Temp
Room Temperature
Molecular Weight
2452 da
SUPPLIER INFO
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