BUY Stromatoxin-1

Stromatoxin-1. A Potent Blocker of K_v2.1, K_v2.1/9.3, K_v2.2, and K_v4.2 channels.

Stromatoxin-1 is a 34 amino acid peptidyl toxin originally isolated from Stromatopelma calceatum tarantula. Structurally, Stromatoxin-1 belongs to the scaffold of structural inhibitor cysteine knot peptide family, which were shown to function as gating modifiers.

Stromatoxin-1 selectively inhibits K_v2.1, K_v2.1/9.3, and K_v4.2 channel currents (IC₅₀ of 12.7 nM, 7.2 nM and 1.2 nM respectively), and is the first high-affinity voltage gating modifier inhibitor of the K_v2.2 channel subtype (IC₅₀, 21.4 nM) to be discovered.

Alomone Labs is pleased to offer Stromatoxin-1, a synthetic product in economical sizes and at very attractive prices.

Ion Channel Modulators; K⁺ Channel Blockers