BUY Stichodactyla Toxin

Stichodactyla Toxin (ShK). K_v�Channel�Blocker

Stichodactyla toxin (ShK) is a peptidyl toxin originally isolated from the nematocyst of the sea anemone Stichodactyla helianthus

ShK blocks K_v1.3, K_v1.1, K_v1.4, and K_v1.6 at subnanomolar concentrations and K_v3.2 channels at 1000-fold higher concentration than that required to inhibit K_v1.3 channels. It has been shown to block K_v current in DRG neurons, to displace radioactive Dendrotoxin from brain synaptosomes and inhibit I125-Charybdotoxin binding to Jurkat T lymphocytes with an IC₅₀ of 32 pM.

Evidence also suggests that native K_v currents in the central nervous system, which are�predominantly carried by K_v1.2 channels, are highly sensitive to this toxin.

A fluorescently labeled synthetic ShK is used to recognize and to sort K_v1.3 containing lymphocytes.

Alomone Labs is pleased to offer rStichodactyla (rShK), a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity.

Ion Channel Modulators; K⁺�Channel Blockers.