Supplier:
Alomone Labs Limited.Cat no: RTS-400
BUY Stichodactyla Toxin
Stichodactyla toxin (ShK) is a peptidyl toxin originally isolated from the nematocyst of the sea anemone Stichodactyla helianthus
ShK blocks Kv1.3, Kv1.1, Kv1.4, and Kv1.6 at subnanomolar concentrations and Kv3.2 channels at 1000-fold higher concentration than that required to inhibit Kv1.3 channels. It has been shown to block Kv current in DRG neurons, to displace radioactive Dendrotoxin from brain synaptosomes and inhibit I125-Charybdotoxin binding to Jurkat T lymphocytes with an IC50 of 32 pM.
Evidence also suggests that native Kv currents in the central nervous system, which areпїЅpredominantly carried by Kv1.2 channels, are highly sensitive to this toxin.
A fluorescently labeled synthetic ShK is used to recognize and to sort Kv1.3 containing lymphocytes.
Alomone Labs is pleased to offer rStichodactyla (rShK), a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity.
Ion Channel Modulators; K+пїЅChannel Blockers.
Prices direct from Alomone Labs Limited.
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SPECIFICATIONS
Catalog Number
RTS-400
Size
5 x 5 micro g
Purity
>98%
Concentration
150 pM - 25 nM
Shipping Temp
Room Temperature
Molecular Weight
4055 da
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