BUY Scyllatoxin

Scyllatoxin.
A Potent Blocker of K\_Ca\2 (SK) K⁺ Channels.

Scyllatoxin is a 31 amino acid long toxin, originally isolated from the Leiurus quinquestriatus hebraeus scorpion venom, and is classified as alpha-KTx 5.1 scorpion toxin family, having three disulfide bridges.
Scyllatoxin was shown to compete with \^125\I -apamin binding in the brain. Furthermore, Scyllatoxin appears to be selective for apamin-sensitive SK channels.
Scyllatoxin inhibits apamin-sensitive SK channel activity in guinea-pig and rabbit hepatocytes, SK currents in human lymphoblastoma cells, and epinephrine-induced relaxation of visceral smooth muscle.
Scyllatoxin also inhibits the apamin-sensitive after hyperpolarization that follows action potentials in skeletal muscle and neurons.

The SK channel-mediated after hyperpolarising current (I\_AHP\) of dorsal vagal neurons, presuming K\_Ca\2.3 (SK3), were blocked by Scyllatoxin (20�30 nM). HEK 293 cell currents stably expressing hK\_Ca\2.1 (hSK1) and K\_Ca\2.2 (hSK2) were blocked by Scyllatoxin with an�IC₅₀ of 80 nM and 287 pM, respectively.

Alomone Labs is pleased to offer Scyllatoxin (#STS-370), a highly potent blocker of K\_Ca\ channels with highest affinity towards K\_Ca\2.2, having the following affinities: K\_Ca\2.2 < < K\_Ca\2.3 < K\_Ca\2.1.

Ion Channel Modulators; K⁺ Channel Blockers