MA5/PK Homolog - p38 Inhibitor
SB203580 is highly selective and cell permeable pyridinyl imidazole that inhibits the activity of MAP kinase homologs - p38 (stress-activated protein kinase II/HOG1) and p54 (stress-activated protein kinase I/c-Jun N-terminal kinase) with IC50 values of 50 and 500 nM for p38/SA5/PK2a and p38/SA5/PK2b respectively. SB203580 also inhibits the phosphorylation and activation of protein kinase B (5/PKB, also known as Akt) by inhibiting the 5/PKB kinase, phosphoinositide-dependent�protein kinase 1 (IC50 3-5 μM). Protein Kinase Inhibitors and Activators; MA5/PK and MA5/PK Homolog Inhibitors
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