Resiniferatoxin. A Potent and Selective Agonist of the TRPV1.
Resiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel. Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons. Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. These responses were followed by a loss of thermoregulation, by desensiization to neurogenic inflammation and by chemical and thermal analgesia, with a cross-tolerance between Resiniferatoxin and capsaicin.
Ion Channel Modulators; TRP Channel Modulators.
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