BUY rat CNTF

rat CNTF
rat Ciliary Neurotrophic Factor
Recombinant, E.coli

CNTF is a polypeptide hormone, member of the alpha-helical cytokine superfamily. It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture. CNTF is synthesized by glia both in the CNS and PNS and it has been demonstrated that CNTF is ubiquitously distributed in neurons and glia throughout the rodent brain. CNTF effects are mediated by a tripartite receptor complex consisting of two signal-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFR).

CNTF can support the survival of many different cell populations within the PNS and the CNS. CNTF in vitro, promote proliferation and neuronal specifications in hippocampal neurons. It supports the viability of non-primate motor neurons, In vivo, CNTF induces sprouting of cholinergic motor neurons and delays neural degeneration in genetic models of motor neuron disease. In addition, it is involved in the development stage of astrocytes and oligodendocytes.

Alomone Labs is pleased to offer rat CNTF, a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity.

Neurotrophic Factors, Neuropoietic Cytokines