BUY QX-314

QX-314 (Cl- salt). A Local Anesthetic Blocker of Na_v Channels.

This local anesthetic is a blocker of voltage-dependent Na⁺ channels. QX-314 blocks all Na_v channels once exposed to the intracellular face of the channel protein. However, this compound can penetrate the cell interior once applied outside the cell. Via certain types of Na_v channels, it can permeate and exert blocking activity via TTX sensitive channels. Intracellular recordings from inferior olivary neurons in brain stem slice preparation demonstrated that Na⁺ - dependent action potential was completely blocked for approximately five minutes after impalement with a microelectrode containing 50 mM QX-314, whereas the low-threshold Ca²⁺ spike was still generated. QX-314 is widely used to block Na_v channels and used as a tool in neurophysiological recordings.
Ion Channel Modulators; K Voltage - Gated Na⁺ Channel Blockers.