QX-222. A Quarternary Derivative of the Local Anesthetic Lidocaine.
QX-222 is a quarternary derivative of the local anesthetic Lidocaine. It was shown to block Nav currents and channels in a use dependent manner. The mechanism of block involves intracellular binding site, but some Nav channels facilitate the passage of QX-222 via the open channel. In addition it was shown to inhibit nicotinic ACh receptor channels.
Ion Channel Modulators; K Voltage - Gated Na+ Channel Blockers.
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