Supplier:
Alomone Labs Limited.Cat no: STP-100
BUY ProTx-II
ProTx-II is a peptidyl toxin originally produced in Thrixopelma pruriens, the Peruvian green velvet tarantula. It was identified as a voltage-gated Na+ channel (Nav) blocker which inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant channels.
Binding of ProTx-II to an extracelluar domain of Nav channel, probably to a hydrophobic site, inhibits current by shifting the channel activation to more positive potentials.
ProTx-II Inhibits Nav1.2, Nav1.3, Nav1.5 , Nav1.6 , Nav1.7 and, Nav1.8. It is a significantly more potent inhibitor against Nav 1.7 than the other Nav channel subtypes.
ProTx-II was also found as an effective modulator which shifts the voltage dependence activity of T-type Ca2+ channel.
Alomone labs is pleased to offer ProTx-II (#STP-100), a highly purified synthetic protein.
Ion Channel Modulators; Voltage - Gated Ca2+пїЅChannel Blockers.
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SPECIFICATIONS
Catalog Number
STP-100
Size
0.1 mg
Purity
>98%
Concentration
10-500 nM.
Shipping Temp
Room Temperature
Molecular Weight
3832.6 da
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