BUY ProTx-I

ProTx-I. Potent Blocker of Na_v�and Cav3 Channels.

Native ProTx-I has been isolated from the venom of the tarantula Thrixopelma pruriens. It was purified on the basis of its ability to reversibly inhibit the tetrodotoxin (TTX)-resistant Na channel Na_v1.8. Structurally, ProTx-I is shown to belong to the inhibitory cystine knot (ICK) family of peptidyl toxins interacting with voltage-gated ion channels. ProTx-I was also found to be an inhibitor for TTX sensitive Na_v channels such Na_v1.5, Na_v1.7 and Na_v1.3 with IC₅₀ values below 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of Cav 3.1 alpha(1G), (IC₅₀~50 nM) without affecting the voltage dependence of inactivation.

Alomone Labs is pleased to offer ProTx-I, a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity.

Ion Channel Modulators; Voltage - Gated Ca²⁺ Channel Blockers; Voltage - Gated Na⁺ Channel Blockers.