Supplier:
Alomone Labs Limited.Cat no: RTP-200
BUY ProTx-I
Native ProTx-I has been isolated from the venom of the tarantula Thrixopelma pruriens. It was purified on the basis of its ability to reversibly inhibit the tetrodotoxin (TTX)-resistant Na channel Nav1.8. Structurally, ProTx-I is shown to belong to the inhibitory cystine knot (ICK) family of peptidyl toxins interacting with voltage-gated ion channels. ProTx-I was also found to be an inhibitor for TTX sensitive Nav channels such Nav1.5, Nav1.7 and Nav1.3 with IC50 values below 100 nM. Furthermore, ProTx-I shifts the voltage dependence activity of Cav 3.1 alpha(1G), (IC50~50 nM) without affecting the voltage dependence of inactivation.
Alomone Labs is pleased to offer ProTx-I, a recombinant peptide expressed in and extracted from E. coli and purified to homogeneity.
Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers; Voltage - Gated Na+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
RTP-200
Size
5 x 5 micro g
Purity
>98%
Concentration
10-100 nM.
Shipping Temp
Room Temperature
Molecular Weight
3987.5 da
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