BUY OsK-1

OsK-1. Potent Inhibitor of K_v1.3 and KCa3.1 K⁺�Channels.
OsK1 (alpha-KTx3.7) is a 38-residue toxin cross-linked by three disulphide bridges, originally isolated from the venom of the Asian scorpion Orthochirus scrobiculosus. The toxin was found to block a number of K⁺ channels, both voltage-dependent and Ca²⁺-activated isoforms. OsK-1 is lethal in mice by intracerebroventricular injection, with a LD50 value of 2 micro g/kg. OsK-1 blocks mK_v1.1, mK_v1.2, mK_v1.3 channels potently and hKCa3.1 channel moderately, with IC₅₀ values of 0.6, 5.4, 0.014 and 225 nM, respectively. No inhibition effects were observed on K_v1.4, K_v1.5, K_v1.6, K_v1.7, K_v11, KCa2.1, KCa2.2, KCa2.3 and KCa1.1 channels at μM concentrations.
Ion Channel Modulators; K⁺�Channel Blockers.