BUY omega-Conotoxin MVIIA

omega-Conotoxin MVIIA. Specific Ca_v2.2 Channel Blocker. omega-Conotoxin MVIIA is a synthetic peptidyl toxin originally isolated from Conus magus snail venom. omega-Conotoxin MVIIA, specifically blocks Ca_v2.2 (alpha1beta, N-type) channels. The effect of the toxin is modulated by Cavbeta auxiliary subunit and by voltage (i.e. it is more potent for inactivated channels).
omega-Conotoxin MVIIA inhibits K⁺-induced H-GABA release in hippocampus in vivo. This effect was with high affinity (50% block, 200 nM).
The toxin was used to inhibit synaptic transmission in several peripheral preparations. The toxin binds with high affinity to rat neocortical membranes. It blocked cloned Ca_v2.2 channels transiently expressed in tsa-2019 and in Xenopus oocytes.
The FDA recently approved Prialt (synthetic omega-Conotoxin MVIIA) to treat severe chronic pain in patients who are intolerant of or refractory to other treatments such as systemic analgesics or morphine.
This is the first ion channel blocker to be marketed for pain.