Supplier:
Alomone Labs Limited.Cat no: N-125
BUY Nicardipine HCI
L-type (Cav1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential. L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases. Dihydropyridines (DHP) are molecules that act as allosteric modulators of L-type channels and many are used in the clinic to treat hypertension.
Nicardipine HCl is a dihydropyridine that acts as L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension. Nicardipine inhibits L- and T-type Cav channels with similar potency. In human coronary myocytes, nicardipine inhibited the Ca2+ currents with an IC50 of ~2 μM, While in porcine coronary artery strips 2 nM nicardipine were effective in inhibiting the constrictive response to of this muscle to endothelin. Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
N-125
Size
5 g
Purity
>99%
Concentration
0.1-100 uM
Shipping Temp
Room Temperature
Molecular Weight
515.9 da
SUPPLIER INFO
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