BUY MitTx

MitTx.

MitTx is a natural toxin isolated from the Texas Coral snake venom.
The purified active toxin consists of a heteromeric complex between Kunitz (alpha subunit) and phospholipase-A2-like (beta subunit) proteins that together function as a potent, persistent and selective agonist for acid-sensing ion channels (ASICs), showing equal or greater efficacy compared with acidic pH.
MitTx-alpha and MitTx-beta form a high affinity 1:1 complex, and neither subunit demonstrates functional effects on its own.
The purified ASIC-activating component of the venom, MitTx, was found sufficient to elicit robust nocifensive behaviors and is likely responsible for the lasting pain experienced by victims of coral snake envenomation.

Alomone labs is pleased to offer MitTx (#M-100), a highly purified natural protein, the first described ASIC1 activator.