BUY mIL-6

mIL-6
mouse Interleukin-6
Recombinant, E. coli

Interleukin-6 (IL-6) is a cytokine involved in a wide variety of biological functions. It plays an essential role in the final differentiation of B-cells into immunoglobulin-secreting cells, nerve cell differentiation and it stimulates hepatocytes to produce acute-phase proteins such as C-reactive protein (CRP), fibrinogen and serum amyloid A protein.

IL-6 and IL-3 synergize in vitro to promote the proliferation of multipotent hematopoietic progenitor cells. In murine bone marrow cultures, IL-6 shows activities resembling those of GM-CSF. IL-6 is also a thrombopoietin that induces the maturation of megakaryocytes in vitro and increases platelet counts in vivo.

IL-6 promotes survival of cholinergic neurons in culture, and some neuronal cell lines can be induced to differentiate by IL-6.

IL-6 is produced by various types of lymphoid and non-lymphoid cells, such as T cells, B cells, monocytes, fibroblasts, endothelial cells, and several tumor cells. It induces growth of T cells and differentiation of cytotoxic T cells. IL-6 acts synergistically with IL-3 to support the formation of multilineage blast cell colonies in hematopoiesis. It also induces differentiation of macrophages, megakaryocytes and osteoclasts.

Neurotrophic Factors, Neuropoietic Cytokines