Mepivacaine hydrochloride
Local anesthetics block propagation of compound action potentials by binding to voltage-gated sodium (Na+) channels but also potently block potassium (K+) currents.
Mepivacaine hydrochloride is a local anesthetic, which has similar time of anesthesia as Lidocaine. Both anesthetics are adequate for surgical procedures that last one hour and there is no difference between them in relation to the severity of dentistry post-operative pain.
Mepivacaine reversibly blocks transient Na+ inward current, as well as steady-state K+ outward current, in sciatic nerve fibers of Xenopus laevis, with half-maximal tonic inhibiting concentrations (IC50) values of 149 uM and 2305 uM, respectively.
It blocks tandem pore domain K+ channel (TASK) with an IC50 value of 709 uM and the open state of hKv1.5 channel.
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