BUY Lidocaine hydrochloride

Voltage-gated Na⁺ channels (Na_V) are plasma membrane protein complexes which allow the passage of Na⁺ ions into cells following a change in the transmembrane voltage. Na_V channels are primarily expressed in the central nervous system. Lidocaine hydrochloride is a local anesthetic of the amino amide group. Drugs of this category induce their effect by binding to the intracellular area of the Na⁺ channel, which blocks the channel's ability to allow Na⁺ to enter the nerve cell, and thus preventing the cell's depolarization. Lidocaine blocks both TTX-sensitive (Na_V1.1, Na_V1.2, Na_V1.3, Na_V1.4, Na_V1.6 and Na_V1.7) and TTX-resistant (Na_V1.5, Na_V1.8 and Na_V1.9) Na_V channels in DRG neurons with IC_{50 of 42 and 210 micro M, respectively. Lidocaine is more effective in blocking the inactivated state (IC50 60 micro M for TTX-resistant in the inactivated state).}