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BUY \nLidocaine hydrochloride

Cat no: L-145

BUY \nLidocaine hydrochloride

Voltage-gated Na+ channels (NaV) are plasma membrane protein complexes which allow the passage of Na+ ions into cells following a change in the transmembrane voltage.\n\nNaV channels are primarily expressed in the central nervous system.\n\nLidocaine hydrochloride is a local anesthetic of the amino amide group. Drugs of this category induce their effect by binding to the intracellular area of the Na+ channel, which blocks the channel's ability to allow Na+ to enter the nerve cell, and thus preventing the cell's depolarization.\n\nLidocaine blocks both TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9) NaV channels in DRG neurons with IC50 of 42 and 210 micro M, respectively. Lidocaine is more effective in blocking the inactivated state (IC50 60 micro M for TTX-resistant in the inactivated state).

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SPECIFICATIONS

Catalog Number

L-145

Size

25 g

Purity

>98%

Concentration

10 uM- 2mM

Shipping Temp

Room Temperature

Molecular Weight

270.8 Da

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