Supplier:
Alomone Labs Limited.Cat no: L-110
BUY L-651,582
Two subtypes of voltage-Gated Ca2+ Channels (VGCC, Cav) are found in most nonexcitable cells, the T-type (Cav3) and the L-Type (Cav1)пїЅ Ca2+ channels.
L-651,582, is an antiproliferative, antiangiogenic, antimetastatic and antiparasitic agent, which is also selective towards numerous mismatch repair-deficient tumor cell lines in vitro. It is a voltage-gated L-type Ca2+ channel blocker with an IC50 of 0.5 μg/ml.
Patch clamp measurements of current through L- and T-type channels in guinea pig atrial cells also indicate that L-651,582 is a Ca2+ antagonist.
Block of L-type calcium channels is voltage-dependent and the apparent dissociation constant for the high affinity state is 0.2 μg/ml. The IC50 for block of T-type Ca2+ channels is 1.4 μg/ml.
Ion Channel Modulators; Voltage - Gated Ca2+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
L-110
Size
10 mg
Purity
>99%
Concentration
0.5-200 uM.
Shipping Temp
Room Temperature
Molecular Weight
424.7 da
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