Supplier:
Alomone Labs Limited.Cat no: K-250
BUY KT5823
KT5823 is a semi-synthetic derivative of K525a. It is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50=234nM). KT5823 interferes at the level of the ATP binding site of the catalytic domain of PKG. The PKG are Ser/Thr protein kinase with broad substrate specificity, and expressed in; brain, smooth muscle cells, platelets, juxtaglomerular kidney cells, and endothelial cells. KT5823 triggered apoptotic DNA fragmentation in immortalized uterine epithelial cells, suggesting a regulatory role for PKG in the apoptotic process in these cells.
Protein Kinase Inhibitors and Activators; PKG Inhibitor.
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SPECIFICATIONS
Catalog Number
K-250
Size
50 micro g
Purity
>98%
Concentration
500 nM - 1 uM
Shipping Temp
Room Temperature
Molecular Weight
495
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