Supplier:
Alomone Labs Limited.Cat no: K-105
BUY KC 12291 hydrochloride
The pathophysiological importance of Na+ overload is highlighted by the fact that a variety of drugs reducing Na+influx proved to be cardioprotective, both at the intact organ and cellular level. In addition, a correlation between the degree of Na+ channel blockade and functional recovery from myocardial infarction is established.
KC 12291 is an orally active atypical voltage-gated sodium channel blocker with cardioprotective properties. It effectively blocks cardiac voltage-gated sodium channels, involving inhibition of the peak Na+ current and thus delays Na+ overload during ischemia by enhancing the inexcitability of the heart.
KC 12291 abolishes diastolic contracture in isolated myocytes obtained from guinea-pig atria, with IC50 values of 0.55 and 0.79 uM, respectively and the IC50 for KC 12291 inhibition of the sustained component of Na+current, INaL, is 9.6 uM.
KC 12291 exerts a potent bradycardic effect in the rat.
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SPECIFICATIONS
Catalog Number
K-105
Size
25 mg
Purity
>97%
Concentration
0.5 - 100 uM
Shipping Temp
Room Temperature
Molecular Weight
449.99 Da
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