BUY Kaliotoxin-1

Kaliotoxin-1.A Powerful Blocker of K\_Ca\1.1 and Certain K\_v\1 Channels.
Kaliotoxin-1 is a 38 amino acid long toxin, originally isolated from the venom of Androctonus mauretanicus mauretanicus scorpion and is classified as alpha-KTX 3.1 scorpion toxin family, having three disulfide bridges. Kaliotoxin-1 is a potent inhibitor of large conductance Ca²⁺-activated K\^+\ channels (BK\_Ca\), and it also binds and inhibits Dendrotoxin sensitive voltage-dependent K\^+\ channels, mainly K_v1.1 (KCNA1), K\_v\1.2 (KCNA2) and K\_v\1.3 (KCNA3) with a Kd of 1.5, 25 and 0.1 nM, respectively. Its binding affinity to rat brain synaptosomes is 5-fold higher than that of Kaliotoxin-3.
The 3D structure of Kaliotoxin was determined by NMR spectroscopy and showed significant differences from structures established for other related scorpion toxins.
In vivo application of Kaliotoxin was shown to facilitate cognitive processes such as learning in rats. Ion Channel Modulators; K⁺ Channel Blockers.