Supplier:
Alomone Labs Limited.Cat no: I-300
BUY Imperatoxin A
The activating effect of IpTxa on skeletal ryanodine receptor is Ca2+ -dependent, synergized by caffeine, and independent of other modulators of RyRs.
IpTxa increased the open probability of rabbit skeletal muscle RyRs by increasing the frequency of open events and decreasing the duration of the closed lifetimes.
IpTxa displays structural homology with an activating segment of the alpha1 subunit of the skeletal dihydropyridine receptor (II-III loop, segment Glu666-Leu690) which is putatively the native activator of ryanodine receptor. IpTxa and the segment Glu666-Leu690 activate RyRs in a similar manner and appear to compete for a common binding site on the ryanodine channel protein.
This suggest a common mechanism of IpTxa and dihydropyridine receptor for modulation of RyR.
Alomone Labs is pleased to offer Imperatoxin A a syntetic toxin identical with the natural toxin from the Pandinus imperator venum. Cell Ca2+ Signaling; Intracellular Ca2+ Mobilizers.
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SPECIFICATIONS
Catalog Number
I-300
Size
5 mcg
Purity
>99%
Concentration
10-300 nM
Shipping Temp
Room Temperature
Molecular Weight
3758 da
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