BUY Huwentoxin-IV

Huwentoxin-IV. A Potent Blocker of Neuronal TTX Sensitive Voltage-Gated Na \^+\ Channel.

Huwentoxin-IV is a 35 amino acid peptidyl toxin isolated from the tarantula Haplopelma schmidti venom and its structure represents a typicalcystine knot motif.
Huwentoxin-IV acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated Na\^+\ channels, with an IC \_50\of 30 nM in rat DRG neurons.
It preferentially inhibits central neuronal voltage-gated Na\^+\ channel subtypes: hNa_v1.7 (IC \_50\of 26 nM), rNa_v1.2 (IC \_50\ of 150 nM), and rNa_v1.3 (IC \_50\of 338 nM), compared with muscle subtypes rNa_v1.4 and h Na_v1.5 (IC \_50\ is > 10 micro M).
Huwentoxin-IV inhibits Na\^+\ channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.
Ion Channel Modulators; Voltage - Gated Na\^+\ Channel Blockers