Supplier:
Alomone Labs Limited.Cat no: STH-100
BUY Huwentoxin-IV
Huwentoxin-IV is a 35 amino acid peptidyl toxin isolated from the tarantula Haplopelma schmidti venom and its structure represents a typicalcystine knot motif.
Huwentoxin-IV acts selectively on tetrodotoxin-sensitive (TTX-S) voltage-gated Na\\+\\ channels, with an IC \\50\\of 30 nM in rat DRG neurons.
It preferentially inhibits central neuronal voltage-gated Na\\+\\ channel subtypes: hNav1.7 (IC \\50\\of 26 nM), rNav1.2 (IC \\50\\ of 150 nM), and rNav1.3 (IC \\50\\of 338 nM), compared with muscle subtypes rNav1.4 and h Nav1.5 (IC \\50\\ is > 10 micro M).
Huwentoxin-IV inhibits Na\\+\\ channels by trapping the voltage sensor of domain II of the site 4 in the inward, closed configuration.
Ion Channel Modulators; Voltage - Gated Na\\+\\ Channel Blockers
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SPECIFICATIONS
Catalog Number
STH-100
Size
50 micro g
Purity
>99%
Concentration
20 nM - 500 nM
Shipping Temp
Room Temperature
Molecular Weight
4106 da
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