Supplier:
Alomone Labs Limited.Cat no: RTH-400
BUY Hongotoxin-1
Hongotoxin was originally isolated from the scorpion Centruroides limbatus and was shown to block cloned and heterologously expressed (in HEK 293 cells) Kv1.1, 1.2 and 1.3 with IC50 of 31, 170 and 86 pM respectively. In addition, it blocks Kv1.6 with low affinity (IC50 = 6nM). Hongotoxin-1 action was examined by monitoring radiolabeled Rb+ efflux from Kv channels-transfected HEK 293 cells. Hongotoxin-1 blocks 125I-Margtoxin (Margatoxin) binding to rat brain synaptosomes or 125I-Kaliotoxin binding to purified Kv1.3-KcsA chimeras. A mutated 125I-Hongotoxin-1 was used to immunoprecipitate (with specific Kv antibodies) rat brain Kv channels and to determine their subunit composition.
Ion Channel Modulators; K+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
RTH-400
Size
10 micro g
Purity
>98%
Concentration
0.1-0.2 pM.
Shipping Temp
Room Temperature
Molecular Weight
4220 da
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