BUY hGDNF

hGDNF
human Glial-Derived Neurotrophic Factor
recombinant, E. coli

Glial-Derived Neurotrophic Factor (GDNF) is a member of the TGF-beta superfamily. GDNF signals through a multi-component receptor system, composed of a RET protooncogene and one of the four alpha1-alpha4 receptors.

GDNF promotes survival of various neuronal cells, including motoneurons, Purkinje cells and sympathetic neurons. In embryonic midbrain cultures, GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Cells that express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes, and skeletal muscle cells.

In vivo, following transection of facial motor neuron axons, locally applied GDNF has been shown to rescue virtually all damaged neurons from death. GDNF may be of clinical relevance in the treatment of Parkinson's disease that is characterized by progressive degeneration of midbrain dopaminergic neurons.

Neurotrophic Factors, GDNF Family