Heteropodatoxin-2. A Potent Blocker of Kv4 K+ Channel.
Heteropodatoxin-2 is a synthetic peptide purified to homogeneity, originally isolated from the Heteropoda venatoria spider venom. Heteropodatoxin-2 is an inhibitor of voltage-gated K+ channels of the KV4 family. Inhibition of KV4.3 and KV4.2 is strongly voltage-dependent, while inhibition of KV4.1 shows less voltage-dependence.
Heteropodatoxin-2 lacks affinity for KV1.4, KV2.1 and KV3.4. It also blocks Ca2+ channels.
Ion Channel Modulators; K+ Channel Blockers.
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