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BUY HA-1077

Cat no: H-220

BUY HA-1077

Rho/Rok Inhibitor. HA-1077 is a small, cell permeable derivative of isoquinoline which specifically inhibits the small GTPase - Rho by inhibition of its associated kinase-Rho dependent kinase (ROK). This signaling pathway acts as a molecular switch to control cytoskeleton organization in many cell types including smooth muscle. By inhibition of ROK, HA-1077 decreases the myosin light chain (MLC) phosphorylation induced by Ca2+ due to abrogating Rho-mediated inhibition of MLC dephosphorylation. HA-1077 also inhibits fetal calf serum-induced proliferation and \\[\\\\3\\\\H]\\thymidine incorporation into DNA of growth-arrested VSMC in a dose-dependent manner. At concentrations higher than 5 μM, it induces disorganization of actin filament structure. This compound was also found to act as a vasodilator and antivasospasm drug which antagonizes the verapamil-insensitive voltage dependent Ca2+ channel and is used clinically for treatment of the cerebral vasospasm after subarachnoid hemorrhage. Cell Signaling Activators and Inhibitors; Rho/Rok Inhibitor.

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SPECIFICATIONS

Catalog Number

H-220

Size

5 mg

Purity

>99%

Concentration

>1micro M

Shipping Temp

Room Temperature

Molecular Weight

364.3

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