Supplier:
Alomone Labs Limited.Cat no: STG-200
BUY Guangxitoxin-1E
Guangxitoxin-1E is a 36 amino acid peptidyl toxin isolated from the Chilobrachys jingzhao (Chinese earth tiger) tarantula venom and belongs to the huwentoxin-1 family.
Guangxitoxin-1E is a gating modifier of K\\v\\2.1 (KCNB1, IC50 of 1 nM), K\\v\\2.2 (KCNB2, IC50 of 3 nM) and K\\v\\4.3 (KCND3, IC50 of 50 nM) channels. In pancreatic betacells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations.
The physiological modulation of K\\v\\2.1 channels during glucose-induced insulin secretion is MgATP-mediated. No significant effect was found on K\\v\\1.2 (KCNA2), K\\v\\1.3 (KCNA3), K\\v\\1.5 (KCNA5), K\\v\\3.2 (KCNC2), Cav1.2 (CACNA1C), Cav2.2 (CACNA1B), Nav1.5 (SCN5A), Nav1.7 (SCN9A) or Nav1.8 (SCN10A) channels.
Ion Channel Modulators; K+ Channel Blockers
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SPECIFICATIONS
Catalog Number
STG-200
Size
5 x 0.1 mg
Purity
>98 %
Concentration
1 nM - 100 nM
Shipping Temp
Room Temperature
Molecular Weight
3948.7 da
SUPPLIER INFO
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