BUY GsMTx-4

GsMTx-4
A Blocker of Voltage-Gated \_v\1.7 Na\^+\Channels.

This product is not for sale in the United States of America.

GsMTX-4 is a 34 amino acid peptidyl toxin isolated from the Grammostola rosea (Chilean rose) tarantula venom and belongs to the huwentoxin-1 family.
This toxin inhibits different channels and in addition has antimicrobial activity. It blocks cation-selective mechanosensitive ion channels (strech-activated channels, SACs), without having effect on whole-cell voltage-sensitive currents.
In addition, it inhibits atrial fibrillation as well as the membrane motor of outer hair cells at low doses. A medium toxicity on a large spectra of voltage-gated Na\^+\channels, namely \_v\1.1, \_v\1.2, \_v\1.3, \_v\1.4, \_v\1.5, \_v\1.6 and \_v\1.7 was reported.
GsMTx-4 also inhibits K\^+\ channels K\_v\11.1 and K\_v\11.2, whereas it does not inhibit K\^+\ channels K\_V\1.1 (ICK\_50\ > 85 μM), K\_V\1.4 (ICK\_50\ > 85 μM) and K\_V\11.3 (ICK\_50\ = 53 μM).
GsMTX-4 was also found to inhibit both TRPC1 and TRPC6 channels.

Antimicrobial activity is shown against several Gram-positive and Gram-negative bacteria as well.

Ion Channel Modulators; Voltage - Gated Na⁺ Channel Blockers, TRP Channel Modulators