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BUY (G)-Aminobutyric acid

Cat no: G-110

BUY (G)-Aminobutyric acid

(G)-aminobutyric acid (GABA) is an amino acid derivate, synthesized from glutamate by the pyridoxal-L-phosphate (PLP)-dependent enzyme, glutamate decarboxylase (GAD). GABA provides the primary inhibitory signaling in the adult mammalian brain (CNS), and, to some degree of controversy, exerts a depolarizing response in the developing brain.\n\nGABA is an agonist of two main receptor classes in the CNS: GABAA, an ionic ligand gated channel, and GABAB, a metabotrophic, G-protein coupled receptor. GABAA is assembled by 5 out of 16 possible subunits with (A), (B) and either a (G) or a (D) (2:2:1 stoichiometry) being the most common. With an EC50 between 3 - 12micro M it interacts with GABA to allow either an influx or an efflux of Cl- ions, into and out of the cell, respectively. GABAB is a heterodimer comprised of the subunits GABAB1 and GABAB2. It reduces neurotransmitter release by inhibiting Ca2+/sup> channels when activated presynaptically, and facilitates inward rectifying potassium channels, postsynaptically.\n\nGABA deficiency is often the prime cause for epilepsy, with other notably disorders being autism, spasticity, anxiety disorders, schizophrenia, and stiff-person syndrome.

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SPECIFICATIONS

Catalog Number

G-110

Size

50 g

Purity

>98%

Concentration

0.1-100 uM

Shipping Temp

Room Temperature

Molecular Weight

103.1 Da

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