BUY FTX-3.3

FTX-3.3. P-type Cav Channel Blocker

FTX is a polyamine component of the venom of the American funnel web spider Agelenopsis aperta, and has been described as a selective antagonist of P-type voltage-dependent Ca²⁺ channels. However, it has been demonstrated that FTX has actions at other sites including NMDA and GABA receptors and also on T-type calcium channels.
FTX-3.3 (reputed to be structurally identical to the native FTX) has been synthesized and shown to block P-type calcium channels in rat cerebellar Purkinje cells. It antagonizes P-, N-, and L-type calcium channels in mammalian Purkinje and superior cervical ganglia neurons with similar potencies; Its IC₅₀ against P-, N-, and L-type channels are ~0.13 mM, ~0.24 mM and ~0.24 mM, respectively.
FTX-3.3 does not reduce whole-cell sodium current recorded from SK.N.SH cells and is therefore ion selective.
Alomone Labs is pleased to offer FTX-3.3 (#F-120).

Ion Channel Modulators; Voltage - Gated Ca²⁺ Channel Blockers.