BUY FS-2

FS-2. L-type Cav channel blocker.
FS-2 is a natural peptidyl toxin isolated from the Dendroaspis p. polylepsis black mamba venom, by a modification of the procedure of Schweitz et al and purified to homogenity. FS2 is an L-type Cav channel blocker. The toxin reduced (�)Bay K 8644-induced [Ca²⁺]in increase, in smooth muscle cells as determined by Ca²⁺ imaging with Fura-2. The IC₅₀ for this effect was 23 nM. FS2 induced relaxation in pre-constricted rat aorta, pulmonary artery and trachea. In addition, it inhibited acetylcholine induced contractions in guinea pig ileum.
Ion Channel Modulators; Voltage - Gated Ca²⁺ Channel Blockers.