BUY Flunarizine dihydrochloride

Flunarizine dihydrochloride.A Potent Blocker of L-type and T-type Ca_v Channels.

L-type (Ca_v1), voltage-gated Ca²⁺ channels are plasma membrane protein complexes which allow the passage of Ca²⁺ ions into cells following depolarization of the membrane potential.
L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases.
Flunarizine dihydrochloride is a diphenylmethylpiperazine L-type, voltage-gated Ca²⁺ channel blocker and is used in the clinic to treat migraine. Flunarizine dihydrochloride inhibits L- and T-type Ca_v channels in guinea pig ventricular cells with similar potency and in a use dependent manner.

Ion Channel Modulators; Voltage - Gated Ca²⁺ Channel Blockers.