Supplier:
Alomone Labs Limited.Cat no: F-105
BUY Felodipine
L-type (Cav1), voltage-gated Ca2+ channels are plasma membrane protein complexes which allow the passage of Ca2+ ions into cells following depolarization of the membrane potential.
L-type channels are widely expressed in cardiac and smooth muscle in which they control contraction and therefore were recognized as a therapeutic target for cardiovascular diseases.
Dihydropyridines (DHP) are molecules that act as allosteric modulators of L-type channels and many are used in the clinic to treat hypertension. Felodipine is a DHP that acts as L-type, voltage-gated Ca2+ channel blocker and is used in the clinic to treat hypertension.
Felodipine is used as a pharmacological tool to specifically target L-type channels in expression systems as well as in physiological preparations.
The effective concentration of felodipine varies between systems for example; it is higher for inhibition of smooth muscle high K\\+\\ induced contraction than for inhibition of the intracellular Ca2+ elevation in these cells.
Ion Channel Modulator; Voltage - Gated Ca2+ Channel Blockers
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SPECIFICATIONS
Catalog Number
F-105
Size
50 mg
Purity
>99%
Concentration
1-10 uM
Shipping Temp
Room Temperature
Molecular Weight
384.25 da
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