Fasciculin-II is a 61 amino acid peptidyl toxin with four disulfide bonds, isolated from the Eastern green mamba (Dendroaspis angusticeps) venom. Fasciculin-II belongs to the three finger protein of Elapida toxin family. Fasciculin-II differs from Fasciculin-I only at one position by a Replacement for Tyr with Asp or Asn. Fasciculin-II was shown to be a selective potent and reversible blocker of acetylcholinesterase by binding to the peripheral site of the enzyme. Injection of Fasciculin-II to mice causes severe, generalized, and long-lasting twitching (fasciculation) due to its ability to prevent degradation and therefore promote acetylcholine accumulation at the neuromuscular junction.
Alomone Labs is pleased to offer Fasciculin-II (#F-225), a natural native toxin purified to homogeneity from the venom of the Eastern green mamba Dendroaspis angusticeps.
Neurotoxins> Anticholinesterase Polypeptide Toxins
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