BUY E-4031

E-4031. A Blocker of K_v11.1 (hERG) K⁺�Channels.
E-4031 is a methanesulfonanilide class III antiarrhythmic agent known to inhibit K_v11.1 (hERG) channels. Sub-micromolar concentration of E-4031, selectively blocks K_v11.1 channels, either in heterologous systems, cardiac cells and cardiac preparations. E-4031 was shown to rescue the functional expression of mutated (LQ2) K_v11.1 channels in HEK cells. E-4031 (40 μM) treatment also prevented FAK phosphorylation and Rac1 activity (only in HEK cells expressing the K_v11.1 subunit). In rat carotid chemoreceptor cells, 1 μM E-4031 inhibited the K_v current, to a larger extent in postnatal cells, establishing the developmental disappearance of K_v11.1 channels and their contribution to the response to hypoxia. E-4031 (1 μM) accelerated myoblast fusion, probably by blocking K_v11.1 channels that leads to depolarization.
Ion Channel Modulators> K⁺ Channel Blockers.