Supplier:
Alomone Labs Limited.Cat no: E-500
BUY E-4031
E-4031 is a methanesulfonanilide class III antiarrhythmic agent known to inhibit Kv11.1 (hERG) channels. Sub-micromolar concentration of E-4031, selectively blocks Kv11.1 channels, either in heterologous systems, cardiac cells and cardiac preparations. E-4031 was shown to rescue the functional expression of mutated (LQ2) Kv11.1 channels in HEK cells. E-4031 (40 μM) treatment also prevented FAK phosphorylation and Rac1 activity (only in HEK cells expressing the Kv11.1 subunit). In rat carotid chemoreceptor cells, 1 μM E-4031 inhibited the Kv current, to a larger extent in postnatal cells, establishing the developmental disappearance of Kv11.1 channels and their contribution to the response to hypoxia. E-4031 (1 μM) accelerated myoblast fusion, probably by blocking Kv11.1 channels that leads to depolarization.
Ion Channel Modulators> K+ Channel Blockers.
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SPECIFICATIONS
Catalog Number
E-500
Size
1 mg
Purity
>98%
Concentration
100 nM - 1 micro M.
Shipping Temp
Room Temperature
Molecular Weight
510.5 da
SUPPLIER INFO
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